A Genome-Wide Association Study of Gout in People of European Ancestry

Source

Arthritis & Rheumatolgy

Authors

Merriman, TR; Cadzow, M; Merriman, ME; Phipps-Green, A; Topless, R; Abhishek, A; Andres, M; Bradbury, LA; Buchanan, R; Cremin, K; De Guzman, E; de Zoysa, J; Doherty, M; Hill, C; Huizinga, TWJ; Jansen, T; Janssen, M; Joosten, LAB; Kurreeman, F; Lester, S; Liote, F; Macartney-Coxson, D; Matsuo, H; McCarthy, GM; McCormick, S; Murphy, R; Pavelka, K; Perez-Ruiz, F; Puig, J; Radstake, TRDJ; Riches, P; Rischmueller, M; Roddy, E; Smith, M; Stahl, EA; Stiburkova, B; Stubbs, R; Tausche, AK; Torres, R; Walker, R; Yamamoto, K; Brown, MA; Choi, HK; Dalbeth, N; Miner, JN; So, A; Stamp, LK; Major, T

Department

Health Science

Abstract

All seven loci have been previously associated with serum urate levels in GWAS. Our data emphasise the relative importance of genetic control of serum urate, compared to the genetic control of MSU crystal formation or the innate immune response, in determining gout.

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